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head) in both WT (D1) and Notch1-/- (D2) at one week after 4-OHT treatment. Red: rhodamine, Blue: DAPI; scale bar: 100 .doi: 10.1371/journal.pone.0069113.gpattern of ZO-1 staining (mean fluorescent intensity for Notch1-/- was 117.6?2.9 vs 122.4?8.3 for WT, P = 0.429) suggesting that tight junction formation can ultimately be compensated by other means in vitro.DiscussionIn this study we have dem
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